Objectives

 Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed.

 Methods

  A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined.

 Results

  HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27 P = .012) and 57% by visit 3 (N = 20 P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P > .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P < .04) and linear mixed models (P < .0001).

  Conclusions

 Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.

 Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

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