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Emergence of cancer stem cells in head and neck squamous cell carcinoma: A therapeutic insight with literature review
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Priyanka Rastogi *   |
| I.T.S. Center for Dental Studies and Research, Muradnagar, Ghaziabad, |
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Abstract: (2099 Views) |
Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and neck squamous cell carcinoma (HNSCC), as with other malignancies, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis, and treatment resistance. In this article, the author summarizes the current knowledge of the role of CSCs in HNSCC and discusses the therapeutic implications and future directions of this field.
Source: Dental Research Journal Full Text |
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| Keywords: CSC, field cancerization, HNSCC, metastasis, tumorigenesis |
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Type of Study: Research |
Subject:
Oral and Maxillofacial Pathology
Received: 2012/11/18 | Published: 2012/01/15
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